The left and right ventricles of the four-chambered heart have distinct developmental\norigins and functions. Chamber-specific developmental programming underlies the differential gene\nexpression of ion channel subunits regulating cardiac electrophysiology that persists into adulthood.\nHere, we discuss regional specific electrical responses to genetic mutations and cardiac stressors,\ntheir clinical correlations, and describe many of the multi-scale techniques commonly used to analyze\nelectrophysiological regional heterogeneity
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